A potential new way to treat some of the most common blinding diseases
Many eye diseases exhibit increased permeability of blood vessels in the macular portion of the retina leading to abnormal fluid accumulation and vision loss. Therapies targeting a specific cytokine, VEGF, have transformed clinical care; however, not all patients respond well. A new report shows that inhibiting a specific signaling molecule, atypical protein kinase C reduces increased vessel permeability and blocks inflammation. Blocking aPKC may help protect vision in potentially blinding eye diseases.